9 New Movies and Shows to Stream This Weekend on Netflix, Prime Video, and More (Sept. 25-27)

Introduction to Your Weekend Watchlist

September is quickly fading away, the fall foliage is beginning to emerge, and television schedules are fully locking into their autumn lineups. This means there is absolutely no shortage of fresh entertainment to keep you engaged across major streaming platforms like Netflix, Prime Video, Apple TV, as well as broadcast and cable networks.

As the streaming landscape continues to expand with more options than ever, finding the right content can feel overwhelming. To help you skip the endless scrolling and get straight to the best entertainment, we have curated and ranked the most notable new releases for the weekend of September 25-27. Whether you are looking for celebrity-driven buddy comedies, high-stakes political intrigue, comforting animated classics, or chilling horror anthologies, this weekend's watchlist has something special for everyone.

Top 9 Movies and Shows to Stream This Weekend

1. ‘Brothers’ (Apple TV)

Genre: Comedy
Release: Available now (2 episodes, ~30 mins each)

Matthew McConaughey and Woody Harrelson team up once again, playing exaggerated versions of themselves. In this hilarious series, Woody retreats to Matthew's Texas ranch after his daughter's wedding falls apart. Complications arise when Matthew's mother drops a bombshell revelation that the longtime best friends might share a biological father. As Woody launches an investigation into his heritage, Matthew is simultaneously trying to manage a high-profile run for governor. Their signature chemistry makes this a must-watch.

2. ‘The Love Hypothesis’ (Prime Video)

Genre: Romantic Comedy
Runtime: 1 hour 52 minutes

Based on Ali Hazelwood’s bestselling romance novel, this feature adaptation follows Olive (Lili Reinhart), a Stanford PhD candidate who impulsively kisses an intimidating professor, Adam Carlsen (Tom Bateman), to convince her best friend she is over an old crush. When Adam realizes he also needs a fake girlfriend, they enter a contractual relationship that naturally complicates as actual feelings begin to surface.

3. ‘A Different World’ (Netflix)

Genre: Comedy-Drama
Release: Available now (10 episodes, ~33 mins each)

Hillman College is back in session. This spin-off/sequel follows Deborah Wayne (Maleah Joi Moon)—the daughter of original series favorites Dwayne Wayne and Whitley Gilbert—as she arrives on campus to forge her own path. Featuring returning cast favorites and nostalgic direction by Debbie Allen, this series bridges generational gaps with plenty of heart and wit.

4. ‘American Horror Story: 13’ (FX/Hulu)

Genre: Horror Anthology
Release: Available now (1 episode, ~42 mins)

Ryan Murphy dives deep into the franchise vault for the milestone thirteenth season of AHS. Bringing back legendary series alumni including Jessica Lange, Sarah Paulson, Evan Peters, and Emma Roberts in fan-favorite throwback roles, this season leans heavily into nostalgia, haunted callbacks, and classic horror tropes.

5. ‘Saturday Night Live’ Season 52 (NBC)

Genre: Sketch Comedy
Premiere Date: Saturday, Sept. 26 at 11:30 p.m. ET

Studio 8H kicks off its 52nd season with a unique New York-centric premiere. Recently crowned basketball champion Jalen Brunson makes his hosting debut, becoming the first NBA player from the Knicks to host the iconic sketch show, alongside musical guest KATSEYE.

6. ‘Line of Fire’ (NBC / Peacock)

Genre: Crime Drama
Release: Available now

This high-octane procedural follows the Hollingsworth family, where every member is embedded in federal law enforcement—including Peter Krause as a Secret Service agent and Hope Davis as a U.S. Marshal. When a standard murder investigation uncovers a conspiracy targeting federal personnel, the dysfunctional family must band together.

7. ‘Best Medicine’ Season 2 (Fox / Hulu)

Genre: Medical Comedy-Drama
Release: Available now

Dr. Martin Best (Josh Charles) returns to Port Wenn, where his precarious medical license and ongoing blood phobia continue to cause chaos. Season 2 amps up the eccentricity with bizarre medical mysteries, local townsfolk shenanigans, and guest stars like Andrea Martin.

8. ‘S.W.A.T. Exiles’ (Starz)

Genre: Action Drama
Premiere Date: Friday, Sept. 25 at 10 p.m. ET

Following a botched raid that pushed Hondo (Shemar Moore) into early retirement, his former commander recruits him to lead a specialized unit comprised of overlooked department outsiders. This iteration shifts toward a more serialized, mystery-driven narrative.

9. ‘Toy Story 5’ (Disney+)

Genre: Animated Comedy-Drama
Runtime: 1 hour 42 minutes

Pixar's beloved franchise returns with a timely premise: toys versus technology. When young Bonnie receives a frog-shaped tablet named Lilypad, Jessie leads Woody, Buzz, and the rest of the gang on a heartwarming mission to preserve traditional playtime.

Final Thoughts

Whether you prefer the cozy nostalgia of classic franchises, laugh-out-loud comedy reunions, or suspenseful procedural dramas, this weekend's streaming lineup offers plenty of ways to unwind. Grab your favorite blanket and enjoy the best entertainment available on your preferred devices.